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3 weeks ago | 
outsourcedpharma.com | Xiaojun Liu |Yeonji Kim |Chris Brown |Jing Zhu |Louis Garguilo
By Xiaojun Liu, Yeonji Kim, Chris Brown, and Jing Zhu
Recombinant adeno-associated virus (rAAV) vectors are pivotal in gene therapy due to their proven safety and efficacy for therapeutic gene delivery. However, low production yields and vector heterogeneity remain significant barriers to scalable, high-quality manufacturing.
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3 weeks ago | 
cellandgene.com | Xiaojun Liu |Yeonji Kim |Chris Brown |Jing Zhu
By Xiaojun Liu, Yeonji Kim, Chris Brown, and Jing Zhu
Recombinant adeno-associated virus (rAAV) vectors are pivotal in gene therapy due to their proven safety and efficacy for therapeutic gene delivery. However, low production yields and vector heterogeneity remain significant barriers to scalable, high-quality manufacturing.
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Jan 27, 2025 | 
cellandgene.com | Elben Guimaraes |Xiaojun Liu |Junwei Sun |Lucia Fernandez |Lucia Fernández
Each approach has its advantages and drawbacks. This guide should help you decide which one, or perhaps a hybrid strategy, is best for your company. Exploring Strategies For Developing Robust AAV PlatformsExplore advanced AAV production platforms that enhance efficiency, scalability, and compliance, paving the way for safe and accessible gene therapies.
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Dec 13, 2024 | 
mdpi.com | Xiaojun Liu
2. Materials and Methods 2.1. Plant MaterialsA bush-type inbred line, CS82, and a wild-type inbred line, CM82, of pumpkin (C. maxima) were obtained from the high generations of self-crossing in our laboratory. The bush trait of CS82 (C. maxima) was transferred from the spontaneous bush-type mutant of pumpkin (C. moschata) found in Shanxi, China [27]. To analyze the inheritance of the bush trait in pumpkin (C. maxima), bush-type line CS82 and wild-type line CM82 were crossed to construct F1 generation.
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Nov 22, 2024 | 
bioprocessintl.com | Xiaojun Liu |Brian Gazaille |Allan Bream |Tereza Pavlištová
Gene therapies are emerging as promising treatments for previously untreatable genetic disorders, with adeno-associated viruses (AAVs) being the preferred vector for gene delivery. However, AAV-based gene therapies face challenges in production, including cost, complexity, and scalability. With the gene therapy market projected to grow significantly, drug developers are seeking platforms that streamline AAV production.
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Nov 22, 2024 | 
cellandgene.com | Xiaojun Liu
By Xiaojun Liu
Gene therapies are rapidly transforming the treatment landscape for previously untreatable genetic disorders, offering new hope to patients worldwide. Among the various delivery methods, adeno-associated viruses (AAVs) have emerged as the vector of choice due to their safety profile and ability to target specific cells effectively.
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Nov 21, 2024 | 
outsourcedpharma.com | Xiaojun Liu |Louis Garguilo
By Xiaojun Liu
Gene therapies are rapidly transforming the treatment landscape for previously untreatable genetic disorders, offering new hope to patients worldwide. Among the various delivery methods, adeno-associated viruses (AAVs) have emerged as the vector of choice due to their safety profile and ability to target specific cells effectively.
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Oct 18, 2024 | 
bioprocessintl.com | Xiaojun Liu
Gene therapies have emerged rapidly as promising treatment options for genetic disorders that previously were considered untreatable, such as cancers, rare diseases, and neurological disorders (1). Adenoassociated viruses (AAVs) are the preferred vector for gene delivery because they can be cultured to relatively high titers and show good long-term transgene expression in vivo (2, 3).
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Feb 21, 2024 | 
nature.com | Xiaojun Liu
AbstractPhotoacoustic imaging is a promising technology for in vivo imaging. However, its imaging performance can be hampered by motion artifacts, especially when dealing with high-rate motion. In this paper, we propose an orthogonal motion correction method that utilizes cross-correlation along orthogonal scan directions to extract accurate motion displacements from the photoacoustic data.
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Feb 12, 2024 | 
onlinelibrary.wiley.com | Yi Zhang |Xiaojun Liu |Peng Li |Xing Wang
CONFLICT OF INTEREST STATEMENT The authors declare no competing interests. REFERENCES , & (2017) Changes in soil C and N stocks and C:N stoichiometry 21 years after land use change on an arable mineral topsoil. Geoderma, 303, 19–26. Available from: https://doi.org/10.1016/j.geoderma.2017.05.002 (1958) The effect of soil drying on humus decomposition and nitrogen availability. Plant and Soil, 10(1), 9–31.
