Xiaolei Zhang

2 months ago | cadiz.cosasdecome.es | Mario Aragón |Jose Vela |Xiaolei Zhang

Descripción Restaurante coreano abierto en el Centro Comercial San Fernando Plaza. La iniciativa es de Mario Aragón, José Manuel Vela y Xiaolei Zhang Zhang, y cuenta con la dirección gastronómica de Juan José Sánchez Marabot, y sirve platos con kimchi (col fermentada, muy típica del país asiático) elaborado por ellos mismos, recetas hechas a la parrilla y platos tradicionales.

Dec 10, 2024 | nature.com | Kejia Li |Shijie Chen |Keyun Wang |Yan Wang |Yuying Ye |Zheng Fang | +14 more

By using a limited-proteolysis strategy that employs a large amount of trypsin to generate peptides directly from native proteins, we found that ligand-induced protein local stability shifts can be sensitively detected on a proteome-wide scale. This enabled us to develop the peptide-centric local stability assay, a modification-free approach that achieves unprecedented sensitivity in proteome-wide target identification and binding-region determination. We demonstrate the broad applications of the peptide-centric local stability assay by investigating interactions across various biological contexts. The peptide-centric local stability assay (PELSA) can be used to determine ligand-binding targets and binding regions on a proteome-wide scale with high sensitivity.