Xiaomeng You

Featured in: Favicon

nature.com Favicon

frontiersin.org Favicon

Articles

Mapping RANKL- and OPG-expressing cells in bone tissue: the bone surface cells as activators of osteoclastogenesis and promoters of the denosumab rebound effect | Bone Research

Oct 17, 2024 | nature.com | Christina M Andreasen |Jesper Thomsen |Albert Kim |Michelle McDonald |Xiaomeng You |Julia Charles | +4 more

AbstractDenosumab is a monoclonal anti-RANKL antibody that inhibits bone resorption, increases bone mass, and reduces fracture risk. Denosumab discontinuation causes an extensive wave of rebound resorption, but the cellular mechanisms remain poorly characterized. We utilized in situ hybridization (ISH) as a direct approach to identify the cells that activate osteoclastogenesis through the RANKL/OPG pathway.

Contact details

Emails

[email protected]

Socials & Sites

Try JournoFinder For Free

Search and contact over 1M+ journalist profiles, browse 100M+ articles, and unlock powerful PR tools.

Start Your 7-Day Free Trial →