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Oct 30, 2024 | 
nature.com | Reyka G. Jayasinghe |Michael Iglesia |John Herndon |Austin N. Southard-Smith |Jacqueline L. Mudd |Alla Karpova | +16 more
AbstractTo study the spatial interactions among cancer and non-cancer cells1, we here examined a cohort of 131 tumour sections from 78 cases across 6 cancer types by Visium spatial transcriptomics (ST). This was combined with 48 matched single-nucleus RNA sequencing samples and 22 matched co-detection by indexing (CODEX) samples. To describe tumour structures and habitats, we defined ‘tumour microregions’ as spatially distinct cancer cell clusters separated by stromal components.
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Oct 17, 2024 | 
nature.com | Christina M Andreasen |Jesper Thomsen |Albert Kim |Michelle McDonald |Xiaomeng You |Julia Charles | +4 more
AbstractDenosumab is a monoclonal anti-RANKL antibody that inhibits bone resorption, increases bone mass, and reduces fracture risk. Denosumab discontinuation causes an extensive wave of rebound resorption, but the cellular mechanisms remain poorly characterized. We utilized in situ hybridization (ISH) as a direct approach to identify the cells that activate osteoclastogenesis through the RANKL/OPG pathway.
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Sep 2, 2024 | 
nature.com | H. Jang |Nakul M. Shah |Ju Heon Maeng |Yonghao Liang |Noah L. Basri |Jiaxin Ge | +3 more
AbstractInhibiting epigenetic modulators can transcriptionally reactivate transposable elements (TEs). These TE transcripts often generate unique peptides that can serve as immunogenic antigens for immunotherapy. Here, we ask whether TEs activated by epigenetic therapy could appreciably increase the antigen repertoire in glioblastoma, an aggressive brain cancer with low mutation and neoantigen burden.
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Apr 10, 2024 | 
gearjunkie.com | Ryan Baker |Morgan Tilton |Albert Kim
perm_identityPersonalised advertising and content, advertising and content measurement, audience research and services developmentdevicesStore and/or access information on a deviceYou can choose how your personal data is used.
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Dec 22, 2023 | 
jdsupra.com | Norman Armstrong |Robert Cooper |Albert Kim
On December 18, 2023, the U.S. antitrust enforcers, the Federal Trade Commission (“FTC”) and the Antitrust Division of the Department of Justice (“DOJ”) (collectively, the “Agencies”), issued their final Merger Guidelines (“Guidelines”) after a four-month public comment period.1 These Guidelines replace the 2010 Horizontal Merger Guidelines (“2010 Guidelines”) and the DOJ’s 2020 Vertical Merger Guidelines.
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Nov 1, 2023 | 
nature.com | Alla Karpova |Yize Li |Austin N. Southard-Smith |Michael Iglesia |Reyka G. Jayasinghe |Matthew Wyczalkowski | +17 more
AbstractChromatin accessibility is essential in regulating gene expression and cellular identity, and alterations in accessibility have been implicated in driving cancer initiation, progression and metastasis1,2,3,4. Although the genetic contributions to oncogenic transitions have been investigated, epigenetic drivers remain less understood.
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Oct 11, 2023 | 
journals.sagepub.com | Albert Kim |Jared M. Novick |Tal Ness
Skip to main contentIntended for healthcare professionalsGet full access to this articleView all access and purchase options for this article. TransparencyAction Editor: Rogier KievitEditor: Interim Editorial PanelReferencesAltmann E. M., Gray W. D. (2008). An integrated model of cognitive control in task switching. Psychological Review, 115(3), 602–639. Altmann G., Steedman M. (1988). Interaction with context during human sentence processing. Cognition, 30(3), 191–238. Badre D. (2008).
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Aug 24, 2023 | 
jdsupra.com | Norman Armstrong |Robert Cooper |Albert Kim
On August 16, 2023, the US Federal Trade Commission (“FTC”) brought its first enforcement action under Section 8 of the Clayton Act in 40 years.1 At the same time, the US Department of Justice’s Antitrust Division (“DOJ” and with the FTC, “Agencies”) continued its recently reinvigorated Section 8 enforcement campaign, announcing that two Pinterest Inc.
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Aug 15, 2023 | 
jdsupra.com | Norman Armstrong |Robert Cooper |Albert Kim
On July 19, 2023, the U.S. antitrust enforcers, the Federal Trade Commission (“FTC”) and the Antitrust Division of the Department of Justice (“DOJ”) (collectively, the “Agencies”), released draft merger guidelines for public comment (“Draft Guidelines”).1 The Draft Guidelines are intended to replace the existing Horizontal Merger Guidelines, last updated in 2010, and the Vertical Merger Guidelines issued in 2020 and provide guidance for both horizontal and vertical mergers.2 The Draft...
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Aug 1, 2023 | 
thejns.org | Manish K. Aghi |Priscilla K Brastianos |Albert Kim |Steven Kalkanis
INTRODUCTIONBrain metastases (BMs), the most common adult intracranial tumor,1 confer a worse prognosis than cancers lacking BMs.2 In this issue of Neurosurgical Focus, we integrate information on advancements in BM management, research that will drive future treatments, and a roadmap for future research.
