Xiaoping Hu

Feb 21, 2024 | mdpi.com | Ruoyu Wang |Xiaoping Hu

1. IntroductionWith the continuous development of industrial technology, ultrasonic processing technology has been widely applied in material processing due to its advantages of a low cutting force, high processing efficiency, and environmental friendliness [1]. In the process of ultrasonic cutting, it is essential for the ultrasonic vibration system to work continuously, without faults, and stably to ensure the quality of the processing.

Jun 27, 2023 | dx.doi.org | Ning Sun |Xiaoping Hu |Tiphaine C Martin |Jingjie Yi

With advances in chemically induced proximity technologies, heterobifunctional modalities such as proteolysis targeting chimeras (PROTACs) have been successfully advanced to clinics for treating cancer. However, pharmacologic activation of tumor-suppressor proteins for cancer treatment remains a major challenge. Here, we present a novel Acetylation Targeting Chimera (AceTAC) strategy to acetylate the p53 tumor suppressor protein.

May 5, 2023 | pubs.acs.org | Ning Sun |Xiaoping Hu |Tiphaine C Martin |Jingjie Yi

With advances in chemically induced proximity technologies, heterobifunctional modalities such as proteolysis targeting chimeras (PROTACs) have been successfully advanced to clinics for treating cancer. However, pharmacologic activation of tumor-suppressor proteins for cancer treatment remains a major challenge. Here, we present a novel Acetylation Targeting Chimera (AceTAC) strategy to acetylate the p53 tumor suppressor protein.