Xiaotian Qi

Sep 9, 2024 | nature.com | Shengchun Wang |Yuan Wang |Yi-Hung Chen |Xiaotian Qi |Hong Yi

AbstractMulti-site functionalization of molecules provides a potent approach to accessing intricate compounds. However, simultaneous functionalization of the reactive site and the inert remote C(sp3)–H poses a formidable challenge, as chemical reactions conventionally occur at the most active site. In addition, achieving precise control over site selectivity for remote C(sp3)–H activation presents an additional hurdle.

Jul 20, 2023 | nature.com | Shengchun Wang |Xiaotian Qi

Author notesThese authors contributed equally: Shengchun Wang, Demin Ren. Authors and AffiliationsInstitute for Advanced Studies (IAS), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, P. R. ChinaShengchun Wang, Demin Ren, Zhao Liu, Dali Yang, Pengjie Wang, Yiming Gao, Xiaotian Qi & Aiwen LeiContributionsA.L. and S.W. conceived the work. S.W. and D.R. designed the experiments and analysed the data. D.R. and S.W. performed the synthetic experiments.

Mar 15, 2023 | nature.com | Xiaotian Qi

AbstractFacile formation of carbon-heteroatom bonds is a long-standing objective in synthetic organic chemistry. However, direct cross-coupling with readily accessible alkenyl acetates via inert C‒O bond-cleavage for the carbon-heteroatom bond construction remains challenging.