Yi-Hung Chen

Sep 9, 2024 | nature.com | Shengchun Wang |Yuan Wang |Yi-Hung Chen |Xiaotian Qi |Hong Yi

AbstractMulti-site functionalization of molecules provides a potent approach to accessing intricate compounds. However, simultaneous functionalization of the reactive site and the inert remote C(sp3)–H poses a formidable challenge, as chemical reactions conventionally occur at the most active site. In addition, achieving precise control over site selectivity for remote C(sp3)–H activation presents an additional hurdle.