Xiaoyu Zhou

Apr 11, 2024 | biorxiv.org | Xiaoyu Zhou |Jingjing Gao |Changcai Huang |Liheng Luo

AbstractBase editors enable the direct conversion of target bases without inducing double-strand breaks, showing great potential for disease modeling and gene therapy. Yet, their applicability has been constrained by the necessity for specific protospacer adjacent motif (PAM). We generated four versions of near-PAMless base editors and systematically evaluated their editing patterns and efficiencies using an sgRNA-target library of 45,747 sequences.

Mar 26, 2024 | bmjopen.bmj.com | Yang Gu |Junchao Xie |Xueyuan Liu |Xiaoyu Zhou

DiscussionIn this retrospective cohort study, we developed and validated a nomogram that incorporates five clinical variables to assess the likelihood of moderate-to-severe SDB in mild AIS patients. Nomograms are widely used in research for risk prediction, calculating individual risk by considering relevant population-specific factors.10–12 Our results showed that the screening tool has good discrimination ability and a satisfactory goodness‐of‐fit.

Feb 8, 2024 | science.org | Eduardo Guimarães |Eric Gardner |Xiaoyu Zhou

Research Article MASS SPECTROMETRY Xiaoyu Zhou https://orcid.org/0000-0002-9840-9159, Zhuofan Wang, [...] , Shuai Li, Xianle Rong, [...] , Jiexun Bu https://orcid.org/0009-0001-2244-7087, Qiang Liu https://orcid.org/0000-0002-8402-029X, and Zheng Ouyang https://orcid.org/0000-0002-7932-0933 [email protected]+4 authors +2 authors fewerAuthors Info & Affiliations Editor’s summary Because proteins, carbohydrates, and nucleic acids occur in just one of two mirror-image geometries in nature,...

Oct 31, 2023 | mdpi.com | Hu Liu |Peifeng Li |Xiaoyu Zhou |Pengyu Wang

This is an early access version, the complete PDF, HTML, and XML versions will be available soon. Open AccessArticleby *, , , , , , and School of Electronic and Information Engineering, Lanzhou Jiaotong University, Lanzhou 730070, China*Author to whom correspondence should be addressed.