Xiaoyun Ye

Jan 15, 2025 | chemistry-europe.onlinelibrary.wiley.com | Danhong Chen |Xiaoyun Ye |Ran Xu |Wanqiong Li

In clinical practice, thymopentin (TP-5) is a commonly utilized immunomodulatory peptide drug. The relatively short half-life of TP-5, however, significantly limits its applicability in immunotherapy. Inspired by the structure of the TLR2 ligand lipopeptide Pam3CSK4, fatty acid-modified TP-5 peptides were designed and synthesized in this study. Utilizing its amphiphilicity, they were sonicated to assemble into nanoparticles with the diameters of approximately 100 nm.