Xintong Cai

Nov 23, 2024 | biorxiv.org | Ricardo Lopez |Ricardo López |Natalie Noble |Özge D. Özçete |Xintong Cai

AbstractGPCR-based fluorescent sensors are widely used to correlate neuromodulatory signaling with brain function. While experiments in transfected cells often reveal selectivity for individual neurotransmitters, sensor specificity in the brain frequently remains uncertain. Pursuing experiments in brain slices and in vivo, we find that norepinephrine and dopamine cross-activate the respective sensors.