Özge D. Özçete

Nov 23, 2024 | biorxiv.org | Ricardo Lopez |Ricardo López |Natalie Noble |Özge D. Özçete |Xintong Cai

AbstractGPCR-based fluorescent sensors are widely used to correlate neuromodulatory signaling with brain function. While experiments in transfected cells often reveal selectivity for individual neurotransmitters, sensor specificity in the brain frequently remains uncertain. Pursuing experiments in brain slices and in vivo, we find that norepinephrine and dopamine cross-activate the respective sensors.

May 23, 2024 | nature.com | Aditi Banerjee |Pascal S. Kaeser |Özge D. Özçete

AbstractA wealth of neuromodulatory transmitters regulate synaptic circuits in the brain. Their mode of signaling, often called volume transmission, differs from classical synaptic transmission in important ways. In synaptic transmission, vesicles rapidly fuse in response to action potentials and release their transmitter content. The transmitters are then sensed by nearby receptors on select target cells with minimal delay.