Xu Li

Nov 5, 2024 | pericles.pericles-prod.literatumonline.com | Jie Zeng |Jun Luo |Xu Li |Yongjie Ye

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Oct 5, 2024 | nature.com | Xu Li |Si Wu |Lianbing Zhang |Jueru Lu |Rong Yang |Yuqi Meng | +5 more

During the wound healing process, the activation of signal transducer and activator of transcription 3 (STAT3) is considered crucial for the migration and proliferation of epithelial cells, as well as for establishing the inflammatory environment. However, an excessive STAT3 activation aggravates scar formation. Here we show that 450 nm blue light and 630 nm red light can differentially regulate the phosphorylation of STAT3 (p-STAT3) and its downstream cytokines in keratinocytes. Further mechanistic studies reveal that red light promotes wound healing by activating the PI3 kinase p110 beta (PI3Kβ)/STAT3 signaling axis, while blue light inhibits p-STAT3 at the wound site by modulating cytochrome c-P450 (CYT-P450) activity and reactive oxygen species (ROS) generation. In a mouse scar model, skin wound healing can be significantly accelerated with red light followed by blue light to reduce scar formation. In summary, our study presents a potential strategy for regulating epithelial cell p-STAT3 through visible light to address skin scarring issues and elucidates the underlying mechanisms. In mouse keratinocytes, upregulation of PI3Kβ by red light promotes p-STAT3 and accelerates skin wound healing, whereas ROS induced by blue light inhibits p-STAT3 and alleviates scar formation.

Sep 17, 2024 | link.aps.org | Jian Wang |Xu Li |Xingyue Ma |Lan Chen

Sliding ferroelectricity is a unique type of polarity recently observed in van der Waals bilayers with a suitable stacking. However, electric-field control of sliding ferroelectricity is hard and could induce large coercive electric fields and serious leakage currents that corrode the ferroelectricity and electronic properties, which are essential for modern two-dimensional electronics and optoelectronics.

Sep 10, 2024 | onlinelibrary.wiley.com | Xueqi Wang |Xu Li |Xia Chen |Zhengdou Li

Conflict of Interests The authors declare no conflict of interest. References 1, , , et al., Biomed. Pharmacother. 2020, 132, 110806. 2, , , , , Front. Microbiol. 2022, 13, https://doi.org/10.3389/fmicb.2022.859206. 3, , , et al., Nutrients 2019, 11 (12), 3067. 4, et al., Clin. Chim. Acta 2021, 523, 304–314. 5, , , , , Aging 2021, 13 (17), 21309–21324. 6, , et al., Int. J. Biol. Macromol. 2019, 141, 1013–1021. 7C. Liu, H. Hua, H. K. Zhu, et al., Int. J. Biol. Macromol. 2021, 185, 804-812.

Aug 22, 2024 | chine.in | Xiao Jiuyang |Zhang Bowen |Xu Li

Un porte-parole militaire chinois a déclaré jeudi que le commandement du Théâtre d'opérations de l'est de l'Armée populaire de Libération avait suivi et surveillé le destroyer américain USS Ralph Johnson tout au long de son passage dans le détroit de Taiwan.