Xuewen Pang

3 weeks ago | prod--journal.elifesciences.org | Jie Zhang |Hui Tang |Haoming Wu |Xuewen Pang

eLife Assessment This study presents a useful reassessment of the potential role of dendritic cell-derived IL-27 p28 cytokine in the functional maturation of CD4+CD8- thymocytes, and CD4+ recent thymic emigrants. The evidence supporting the claims of the authors is solid and serves to reaffirm what has been previously described, with the overall advance in understanding the mechanism(s) responsible for the intrathymic functional programming of CD4+ T cells being limited.

Mar 6, 2024 | biorxiv.org | Jie Zhang |Hui Tang |Haoming Wu |Xuewen Pang

AbstractThe newly generated CD4 single-positive (SP) T lymphocytes are featured by enhanced IL-4 but repressed IFN-γ production. The mechanisms underlying this functional bias remain elusive. Previous studies have reported that CD4+ T cells from mice harboring DC-specific deletion of IL-27p28 display an increased capacity of IFN-γ production upon TCR stimulation.