Jie Zhang

3 weeks ago | prod--journal.elifesciences.org | Jie Zhang |Hui Tang |Haoming Wu |Xuewen Pang

eLife Assessment This study presents a useful reassessment of the potential role of dendritic cell-derived IL-27 p28 cytokine in the functional maturation of CD4+CD8- thymocytes, and CD4+ recent thymic emigrants. The evidence supporting the claims of the authors is solid and serves to reaffirm what has been previously described, with the overall advance in understanding the mechanism(s) responsible for the intrathymic functional programming of CD4+ T cells being limited.

3 weeks ago | biorxiv.org | Jie Zhang |Wenxuan Wu |Yun Wang |Youping Zhang

AbstractDespite the high efficacy of all-trans retinoic acid (ATRA) and arsenic trioxide (ATO) in treating acute promyelocytic leukemia (APL), approximately 10-20% of patients develop drug resistance due to mutations in PML-RARα and other factors. Here, it is demonstrated that inhibiting USP2 with ML364 or silencing USP2 reduces PML-RARα protein levels in both ATRA-sensitive and -resistant APL cells, an effect reversed by proteasome inhibition.

1 month ago | biorxiv.org | Jie Zhang |Jiangning Li |Xi'an Jiaotong-Liverpool

AbstractBackground: Dendrobium Officinale is a rare Chinese herbal medicine, and its stem has various medical effects. Currently, the sprouts of Dendrobium Officinale can be mass-produced by stem-cell technology, but its biological active ingredients and medical effects are unknown. The therapeutic ability of the stem cell-originated Dendrobium Officinale (SDO) for allergic rhinitis (AR) was demonstrated in the preliminary experiment on mice.

Dec 5, 2024 | biorxiv.org | Yiqi Sun |Jie Zhang |Qianyun Wang |Jianguang Ni

AbstractBackground: High-precision behavior tracking and closed-loop intervention are essential for studying the neural basis of cognition and behavior. Existing commercial systems are costly and lack flexibility for customization, while current open-source tools often have limitations regarding real-time functionality, device synchronization, and ease of use. New method: We developed RpiBeh, an open-source, cost-effective, and versatile software tailored for rodent neuroethological research.

Jun 28, 2024 | biorxiv.org | Jie Zhang |Xiaocang Zhu |Huihui Zhou |Shuo Wang

AbstractGoal-directed visual attention is a fundamental cognitive process that enables animals to selectively focus on specific regions of the visual field while filtering out irrelevant information. However, given the domain specificity of social behaviors, it remains unclear whether attention to faces versus non-faces recruits different neurocognitive processes.