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Dec 5, 2024 | 
biorxiv.org | Yiqi Sun |Jie Zhang |Qianyun Wang |Jianguang Ni
AbstractBackground: High-precision behavior tracking and closed-loop intervention are essential for studying the neural basis of cognition and behavior. Existing commercial systems are costly and lack flexibility for customization, while current open-source tools often have limitations regarding real-time functionality, device synchronization, and ease of use. New method: We developed RpiBeh, an open-source, cost-effective, and versatile software tailored for rodent neuroethological research.
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Jun 28, 2024 | 
biorxiv.org | Jie Zhang |Xiaocang Zhu |Huihui Zhou |Shuo Wang
AbstractGoal-directed visual attention is a fundamental cognitive process that enables animals to selectively focus on specific regions of the visual field while filtering out irrelevant information. However, given the domain specificity of social behaviors, it remains unclear whether attention to faces versus non-faces recruits different neurocognitive processes.
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Jun 28, 2024 | 
biorxiv.org | Jie Zhang |Runnan Cao |Xiaocang Zhu |Huihui Zhou
AbstractVisual attention and object recognition are two critical cognitive functions that significantly influence our perception of the world. While these neural processes converge on the temporal cortex, the exact nature of their interactions remains largely unclear. Here, we systematically investigated the interplay between visual attention and object feature coding by training macaques to perform a free-gaze visual search task using natural face and object stimuli.
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Jun 28, 2024 | 
biorxiv.org | Jie Zhang |Huihui Zhou |Shuo Wang
AbstractFoveal and peripheral vision are two distinct modes of visual processing essential for navigating the world. However, it remains unclear if they engage different neural mechanisms and circuits within the visual attentional system.
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May 3, 2024 | 
biorxiv.org | Yong Liang |Jie Zhang |Simin Li |Yao Tan
AbstractSuper-resolution structured illumination microscope (SR-SIM) has been established as a powerful tool for visualizing subcellular dynamics and studying organelle interactions in live cells. However, the interfering Gaussian beams result in a limited and nonuniform field of view (FOV) which hinders its application for large whole-cell dynamics and pathological sample imaging.
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Apr 26, 2024 | 
biorxiv.org | Jie Zhang |Rizaldy Zapata |Dongmin Jim Yoon |Martina Ulivieri
AbstractAnorexia nervosa (AN) is an eating disorder observed primarily in girls and women, and is characterized by a low body mass index, hypophagia, and hyperactivity. The activity-based anorexia (ABA) paradigm models aspects of AN, and refers to the progressive weight loss, hypophagia, and hyperactivity developed by rodents exposed to time-restricted feeding and running wheel access.
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Apr 20, 2024 | 
biorxiv.org | Jie Zhang |Leiyu He |Mary Bruns |Tengge Zhang
AbstractAlgal-bacterial granules have been drawing attention in wastewater treatment due to their rapid settling ability and efficient nutrient removal performance. This study evaluated the impact of air flow rates on nitrogen removal and the formation of algal-bacterial granules in domestic wastewater treatment. The highest nitrogen removal efficiency was achieved by operating with two separate feedings and the addition of an external carbon source.
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Apr 7, 2024 | 
biorxiv.org | Jie Zhang |Gongcheng Hu |Yuli Lu |Huawei Ren
AbstractThe three-dimensional genome structure organized by CTCF is required for development. Clinically identified mutations in CTCF have been linked to adverse developmental outcomes. Nevertheless, the underlying mechanism remains elusive.
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Mar 6, 2024 | 
biorxiv.org | Jie Zhang |Hui Tang |Haoming Wu |Xuewen Pang
AbstractThe newly generated CD4 single-positive (SP) T lymphocytes are featured by enhanced IL-4 but repressed IFN-γ production. The mechanisms underlying this functional bias remain elusive. Previous studies have reported that CD4+ T cells from mice harboring DC-specific deletion of IL-27p28 display an increased capacity of IFN-γ production upon TCR stimulation.
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Dec 16, 2023 | 
biorxiv.org | Zeguan Wang |Jie Zhang |Panagiotis Symvoulidis |Wei Guo
AbstractNeurons interact in networks distributed throughout the brain. Although much effort has focused on whole-brain calcium imaging, recent advances in genetically encoded voltage indicators (GEVIs) raise the possibility of imaging voltage of neurons distributed across brains. To achieve this, a microscope must image at high volumetric rate and signal-to-noise ratio.
