Xunzhi Zhang

Dec 20, 2024 | science.org | Robyn Scott |Luiza Tunes |Meng-Hsiung Hsieh |Ping Wang |Ashwani Kumar |Brijesh B Khadgi | +8 more

Published In Science AdvancesVolume 10 | Issue 51December 2024Article versionsSubmission historyReceived: 14 August 2024Accepted: 14 November 2024PermissionsRequest permissions for this article. AcknowledgmentsWe thank O. Koczy, J. Parker, and R. Setlem for contributing to preliminary studies. We are grateful for the helpful discussions with B. Xhemalce on genomic data analysis. The Structural Biology Laboratory at UT Southwestern for help with synchrotron data collection.

Oct 15, 2024 | nature.com | Andrew Boucher |Xunzhi Zhang |Chao Xing

AbstractCholera toxin (CT) is the etiological agent of cholera. Here we report that multiple classes of fucosylated glycoconjugates function in CT binding and intoxication of intestinal epithelial cells. In Colo205 cells, knockout (KO) of B3GNT5, which encodes an enzyme required for synthesis of lacto and neolacto series glycosphingolipids (GSLs), reduces CT binding but sensitizes cells to intoxication.