Yafeng Lyu

Nov 19, 2024 | nature.com | Na Zhang |Hanyue Wang |Xiaofei Li |Yafeng Lyu |Jiahui Liu |Yan Wang | +6 more

AbstractMénière’s disease (MD) is a complex inner ear disorder characterized by a range of symptoms, with its pathogenesis linked to immune-related mechanisms. Our previous research demonstrated that IL-1β maturation and release can trigger cell pyroptosis, exacerbating the severity of the endolymphatic hydrops in a mouse model; however, the specific mechanism through which IL-1β influences MD symptoms remains unclear.