Yalong Wang

Aug 14, 2024 | digitalcommons.library.tmc.edu | Yalong Wang |Mark T. Bedford

Publication Date4-26-2023JournalBiochemical Society TransactionsAbstractArginine methylation is a ubiquitous and relatively stable post-translational modification (PTM) that occurs in three types: monomethylarginine (MMA), asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA). Methylarginine marks are catalyzed by members of the protein arginine methyltransferases (PRMTs) family of enzymes.

Aug 14, 2024 | digitalcommons.library.tmc.edu | Tanner Wright |Yalong Wang |Sabrina A. Stratton |Manu Sebastian

AbstractStaphylococcal nuclease Tudor domain containing 1 (SND1) protein is an oncogene that 'reads' methylarginine marks through its Tudor domain. Specifically, it recognizes methylation marks deposited by protein arginine methyltransferase 5 (PRMT5), which is also known to promote tumorigenesis. Although SND1 can drive hepatocellular carcinoma (HCC), it is unclear whether the SND1 Tudor domain is needed to promote HCC.