Yan Hu

Jan 16, 2025 | nature.com | Yan Hu

AbstractRetinal image registration is vital for diagnostic therapeutic applications within the field of ophthalmology. Existing public datasets, focusing on adult retinal pathologies with high-quality images, have limited number of image pairs and neglect clinical challenges.

Jan 10, 2025 | insu.hal.science | Byeon-Gak Choi |Yan Hu |Frédéric Moynier |Wei Dai

Pervasive aqueous alteration in the early Solar System revealed by potassium isotopic variations in Ryugu samples and carbonaceous chondrites Mots clés Asteroid Ryugu Hayabusa2 mission Carbonaceous chondrites Stable potassium isotopes Aqueous alteration Fichier principal 1-s2.0-S0019103523004633-am.pdf (650.03 Ko) Télécharger le fichier Origine Fichiers produits par l'(les) auteur(s)

Jan 8, 2025 | nature.com | Hui Gao |Xiaohan Zhai |Yan Hu |Hang Wu

Progestogens commonly used in the clinic include levonorgestrel, etonogestrel, medroxyprogesterone, hydroxyprogesterone, progesterone, desogestrel, and megestrol. Progestogens are widely used for contraception and the treatment of endometriosis, threatened abortion and other diseases. However, the correlation between progestogen use and depression is not clear. Therefore, this study used data from the FDA Adverse Event Reporting System (FAERS) database to assess the relationship between progestogen levels and depression. In this study, all data from the first quarter of 2004 to the third quarter of 2024 were extracted and imported into SAS 9.4 software for data cleaning and analysis. The reporting odds ratio (ROR), proportional reporting ratio (PRR), Bayesian Confidence Propagation Neural Network (BCPNN) and Multi-item Gamma Poisson Shrinker (MGPS) were used for Bayesian analysis and disproportionation analysis. Levonorgestrel, medroxyprogesterone, etonogestrel and desogestrel presented positive signals for depression, and medroxyprogesterone also presented positive signals for major depression. Although none of the progestogens presented positive signals for suicide or self-harm, medroxyprogesterone presented a positive signal for suicidal ideation. Conclusion Analysis of data from the FAERS database revealed that levonorgestrel, medroxyprogesterone, etonogestrel, and desogestrel were correlated with depression. These findings provide real-world evidence of the potential risk of progestogen-related depression.

Dec 19, 2024 | mdpi.com | Yan Hu

1. IntroductionWith the support of the Chinese government policies, new energy devices such as wind power and photovoltaic systems are being extensively integrated into the power grid. It is projected that by 2025, the G province of China will add approximately 18 million kilowatts of wind power and 10 million kilowatts of photovoltaic power. These additions of new energy devices provide green and renewable energy sources.

Jun 12, 2024 | nature.com | Suzanne Schindler |Marc Suárez-Calvet |Ara Khachaturian |Michelle M. Mielke |Yan Hu |Soeren Mattke

AbstractAnti-amyloid treatments for early symptomatic Alzheimer disease have recently become clinically available in some countries, which has greatly increased the need for biomarker confirmation of amyloid pathology. Blood biomarker (BBM) tests for amyloid pathology are more acceptable, accessible and scalable than amyloid PET or cerebrospinal fluid (CSF) tests, but have highly variable levels of performance.