Yanjun Li

Jan 8, 2025 | mdpi.com | Yu ZHANG |Mi Zou |Yanjun Li |Qingrui Chang

All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.

Dec 12, 2024 | mdpi.com | Yanjun Li

1. IntroductionCotton is a vital economic crop worldwide, providing about 35% of the natural fibers used in the textile industry and serving as a significant source of edible oil and livestock feed [1]. Among the cotton species, G. hirsutum has the broadest distribution, accounting for 95% of global cotton production, and continues to be the primary focus of cotton breeding efforts [2].

Nov 23, 2024 | nature.com | Serah Kimani |Laurent Hoffer |Stuart Green |Dalia Barsyte-Lovejoy |Vijayaratnam Santhakumar |Suzanne Ackloo | +5 more

AbstractProteolysis-targeting chimeras (PROTACs) have been explored for the degradation of drug targets for more than two decades. However, only a handful of E3 ligase substrate receptors have been efficiently used. Downregulation and mutation of these receptors would reduce the effectiveness of such PROTACs. We recently developed potent ligands for DCAF1, a substrate receptor of EDVP and CUL4 E3 ligases.

Oct 2, 2024 | biorxiv.org | Zhen Wang |Ziqi Liu |Wei Zhang |Yanjun Li

AbstractAptamers are single-stranded nucleic acid ligands, featuring high affinity and specificity to target molecules. Traditionally they are identified from large DNA/RNA libraries using in vitro methods, like Systematic Evolution of Ligands by Exponential Enrichment (SELEX). However, these libraries capture only a small fraction of theoretical sequence space, and various aptamer candidates are constrained by actual sequencing capabilities from the experiment.

Apr 30, 2024 | mdpi.com | Jinhui Zhao |Yanjun Li |Lijing Liu |Zhongjun Liu

All articles published by MDPI are made immediately available worldwide under an open access license. No specialpermission is required to reuse all or part of the article published by MDPI, including figures and tables. Forarticles published under an open access Creative Common CC BY license, any part of the article may be reused withoutpermission provided that the original article is clearly cited. For more information, please refer tohttps://www.mdpi.com/openaccess.