Yanli Wang

1 month ago | elifesciences.org | Ryan Finnerty |Daniel J Carulli |Akshata Hedge |Yanli Wang

eLife Assessment This important study reports the transcriptomic and proteomic landscapes of the oviducts at four different preimplantation stages during natural fertilization, pseudopregnancy, and superovulation. The supporting data are convincing. This work will be of interest to reproductive biologists and clinicians practicing reproductive medicine.

Nov 25, 2024 | biorxiv.org | Ryan Finnerty |Daniel J Carulli |Akshata Hedge |Yanli Wang

AbstractThe oviduct is the site of fertilization and preimplantation embryo development in mammals. Evidence suggests that gametes alter oviductal gene expression. To delineate the adaptive interactions between the oviduct and gamete/embryo, we performed a multi-omics characterization of oviductal tissues utilizing bulk RNA-sequencing (RNA-seq), single-cell RNA-sequencing (scRNA-seq), and proteomics collected from distal and proximal at various stages after mating in mice.

Nov 2, 2024 | nature.com | Weilin Kong |Tong Dai |Beibei Chen |Yanli Wang |Zheng Zeng |Mintie Pu | +1 more

Variations of individual lifespans within genetically identical populations in homogenous environments are remarkable, with the cause largely unknown. Here, we show the expression dynamic of the Caenorhabditis elegans fatty acid elongase ELO-6 during aging predicts individual longevity in isogenic populations. elo-6 expression is reduced with age. ELO-6 expression level exhibits obvious variation between individuals in mid-aged worms and is positively correlated with lifespan and health span. Interventions that prolong longevity enhance ELO-6 expression stability during aging, indicating ELO-6 is also a populational lifespan predictor. Differentially expressed genes between short-lived and long-lived isogenic worms regulate lifespan and are enriched for PQM-1 binding sites. pqm-1 in young to mid-aged adults causes individual ELO-6 expression heterogeneity and restricts health span and life span. Thus, our study identifies ELO-6 as a predictor of individual and populational lifespan and reveals the role of pqm-1 in causing individual health span variation in the mid-aged C. elegans. Variations in lifespan within genetically identical populations in homogenous environments are remarkable, with the cause largely unknown. Here, the authors show that fatty acid elongase ELO-6 expression in mid-aged animals, influenced by PQM-1, predicts individual longevity in Caenorhabditis elegans isogenic populations.

Oct 31, 2024 | arxiv.org | Juan Cheng |Weiming Li |Tao Xiong |Yanli Wang

Oct 29, 2024 | respiratory-research.biomedcentral.com | Junxiang Chen |Chunxi Zhang |Jun Xie |Xuebin Zheng |Yongzheng Zhou |Jie Wu | +6 more

This is a retrospective observational study. The overview of this study is illustrated in Fig. 1. Lung cancer is mainly divided into non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC). About 80–85% of lung cancer cases are NSCLC, and the subtypes of NSCLC include lung adenocarcinoma (LUAD), lung squamous cell carcinoma (LUSC), and some other types.