Yanpeng Wang

Jan 13, 2025 | nature.com | Wenxi Wang |Weilong Guo |Jie Liu |Zhongfu Ni |Qixin Sun |Yanpeng Wang

AbstractPrecise manipulation of genome structural variations holds great potential for plant trait improvement and biological research. Here we present a genome-editing approach, dual prime editing (DualPE), that efficiently facilitates precise deletion, replacement and inversion of large DNA fragments in plants. In our experiments, DualPE enabled the production of specific genomic deletions ranging from ~500 bp to 2 Mb in wheat protoplasts and plants.