Weilong Guo

Jan 13, 2025 | nature.com | Wenxi Wang |Weilong Guo |Jie Liu |Zhongfu Ni |Qixin Sun |Yanpeng Wang

AbstractPrecise manipulation of genome structural variations holds great potential for plant trait improvement and biological research. Here we present a genome-editing approach, dual prime editing (DualPE), that efficiently facilitates precise deletion, replacement and inversion of large DNA fragments in plants. In our experiments, DualPE enabled the production of specific genomic deletions ranging from ~500 bp to 2 Mb in wheat protoplasts and plants.

Jan 7, 2025 | cell.com | Yingyin Yao |Weilong Guo |Zhaorong Hu |Jie Liu |Jun Ma |Yuan Zong | +9 more

1Frontiers Science Center for Molecular Design Breeding, Key Laboratory of Crop Heterosis and Utilization (MOE), and Beijing Key Laboratory of Crop Genetic Improvement, China Agricultural University, Beijing 100193, China 2National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan 430070, China 3John Innes Centre, Norwich Research Park, Norwich, NR4 7UH, UK 4Department of Biotechnology, Faculty of Science, Mersin University, 33343, Yenişehir, Mersin, Turkey...

Nov 25, 2024 | genomebiology.biomedcentral.com | Wenxi Wang |Zihao Wang |Zhe Chen |Xiaoyu Zhang |Zhen Qin |Lingfeng Miao | +10 more

Publisher Correction: Tagging large CNV blocks in wheat boosts digitalization of germplasm resources by ultra-low-coverage sequencing Publisher Correction Open access Published: 25 November 2024 Genome Biology volume 25, Article number: 298 (2024) Cite this article The Original Article was published on 01 July 2024 Correction: Genome Biol 25, 171 (2024) https://doi.org/10.1186/s13059-024-03315-6 Following publication of the original article [1], the authors identified a typesetting error,...

Apr 12, 2024 | science.org | Melad Henis |Najeeb U Siddiqui |Rachith Aiyappa |Jinpeng Li |Xingbei Liu |Wei Chu | +14 more

Research Article PLANT SCIENCES Jinpeng Li https://orcid.org/0009-0002-0846-0856, Xingbei Liu https://orcid.org/0009-0000-6159-9529, [...] , Shumin Chang https://orcid.org/0009-0000-8804-9172, Wei Chu, [...] , Jingchen Lin, Hui Zhou, Zhuoran Hu, Mancang Zhang, Mingming Xin https://orcid.org/0000-0003-4010-4165, [...] , Yingyin Yao, Weilong Guo https://orcid.org/0000-0001-5199-1359, Xiaodong Xie https://orcid.org/0000-0001-8434-8423, Huiru Peng, Zhongfu Ni, Qixin Sun, Yu Long...

Mar 6, 2024 | nature.com | Zhen Qin |Huiru Peng |Zhaorong Hu |Weilong Guo |Zhongfu Ni |Qixin Sun

AbstractHeat stress threatens global wheat (Triticum aestivum) production, causing dramatic yield losses worldwide. Identifying heat tolerance genes and comprehending molecular mechanisms are essential. Here, we identify a heat tolerance gene, TaSG-D1E286K, in Indian dwarf wheat (Triticum sphaerococcum), which encodes an STKc_GSK3 kinase. TaSG-D1E286K improves heat tolerance compared to TaSG-D1 by enhancing phosphorylation and stability of downstream target TaPIF4 under heat stress condition.