Yasmine Kostoglou

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Transcriptional evidence of reduced BDNF trophic capacity in the post-mortem human midbrain of schizophrenia cases with high inflammation - Translational Psychiatry

1 month ago | nature.com | Jessica Chandra |Yunting Zhu |Alice Petty |William Haynes |Yasmine Kostoglou

AbstractElevated inflammation in the midbrain of ~45% of people with schizophrenia may relate to altered trophic support for neurons. Dopamine neurons require trophic support from Brain-Derived Neurotrophic Factor (BDNF), that signals via the full-length Tropomyosin kinase B receptor (TrkBTK+). The truncated BDNF receptor (TrkBTK-) and the apoptosis-related p75 receptor may counteract the effects of BDNF.

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