Yawei Zhao

Mar 26, 2023 | mdpi.com | Yawei Zhao |Shang Su |Xiaohong Li

Abstract: Simple SummaryThe impact of parathyroid hormone-related protein (PTHrP) and parathyroid hormone receptor 1 (PTH1R or PTHR1) on cancer initiation, growth, and metastasis has been extensively documented in a number of in vitro and in vivo studies. Despite these findings, the attempts to target PTHrP/PTH1R signaling in cancer therapy have not produced successful results in the clinical setting.