Yen-Der Li

Jan 2, 2024 | jci.org | Hojong Yoon |Justine C. Rutter |Yen-Der Li |Benjamin Ebert

Pharmacological manipulation of the ubiquitin-proteasome systemThe majority of induced protein degradation engages the ubiquitin-proteasome system. This pathway leverages a posttranslational modification – the covalent attachment of ubiquitin to a substrate protein through the coordinated, sequential activity of three classes of enzymes (22). First, an E1 ubiquitin-activating enzyme utilizes ATP to adenylate ubiquitin and establish a thioester bond between ubiquitin and the E1 enzyme.

Jun 22, 2023 | pubs.acs.org | Woong Sub Byun |Roman C. Sarott |Inchul You |Yen-Der Li

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