Woong Sub Byun

2 months ago | pubs.acs.org | Woong Sub Byun |Qixiang Geng |Zixuan Jiang |Katherine A. Donovan

2 months ago | dx.doi.org | Woong Sub Byun |Qixiang Geng |Zixuan Jiang |Katherine A. Donovan

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Oct 1, 2024 | biorxiv.org | Woong Sub Byun |Qixiang Geng |Zixuan Jiang |Katherine A. Donovan

AbstractMolecular glue degraders (MGDs) are small molecules that facilitate proximity between a target protein and an E3 ubiquitin ligase thereby inducing target protein degradation. Glutarimide-containing compounds are MGDs that bind to cereblon (CRBN) and recruit neosubstrates. Through explorative synthesis of a glutarimide-based library, we discovered a series of molecules that induce casein kinase 1 alpha (CK1α) degradation.

Sep 26, 2024 | biorxiv.org | Woong Sub Byun |Zhe Zhuang |Jakub Chrustowicz |Zuzanna Kozicka

AbstractSmall molecules that induce protein interactions hold tremendous potential as new medicines, as probes for molecular pathways, and as tools for agriculture. Explosive growth of targeted protein degradation (TPD) drug development has spurred renewed interest in proximity-inducing molecules and especially Molecular Glue Degraders (MGDs).

Sep 23, 2024 | sciencedirect.com | Woong Sub Byun

Chemically induced proximity modalities such as targeted protein degradation (TPD) hold promise for expanding the number of proteins that can be manipulated pharmacologically. However, current TPD strategies are often limited to proteins with preexisting ligands. Molecular glues (e.g. glutarimide ligands for CUL4CRBN), offer the potential to target undruggable proteins.