Yifei Jia

Aug 12, 2024 | pubs.rsc.org | Yifei Jia |Yichang Liu |Yamei Wang |Jinyu Li

Sialylation-Induced Stabilization of Dynamic Glycoprotein Conformations Unveiled by Time-Aligned Parallel Unfolding and Glycan Releasing Mass Spectrometry Sialylation, a critical post-translational modification, regulates glycoprotein structure and function by tuning their molecular heterogeneity. However, characterizing its subtle and dynamic conformational effects at the intact glycoprotein level remains challenging.