Yihua Wu

Jul 1, 2024 | biorxiv.org | Abdul Hannan |Qian Wang |Yihua Wu |Neoklis Makrides

AbstractSrc family kinases (SFKs), including Src, Fyn and Yes, play important roles in development and cancer. Despite being first discovered as the Yes-associated protein, the 0regulation of Yap by SFKs remains poorly understood.

Mar 15, 2023 | nature.com | Guang Lu |Yihua Wu

AbstractPeritoneal metastasis is a key feature of advanced ovarian cancer, but the critical protein required for ovarian cancer metastasis and progression is yet to be defined. Thus, an unbiased high throughput and in-depth study is warranted to unmask the mechanism. Transcriptomic sequencing of paired primary ovarian tumors and metastases unveiled that MAP4K4, a serine/threonine kinase belongs to the Ste20 family of kinases, was highly expressed in metastatic sites.