Yin Zhai

Jun 23, 2023 | science.org | Zhenzhen Wang |Queenie Chang |Yin Zhai

DISCUSSIONOur data identify a drug, DEQ (fig. S2D), that targets the σS response, a mutagenesis network hub (11), and inhibits cipro antibiotic–induced mutagenesis (Fig. 1 and figs. S2 and S3), and identify the step at which it acts (Figs. 2 and 3, A to C) in a defined pathway (35, 39) of cipro-induced mutagenic DNA break repair. DEQ blocks induction of the stringent starvation stress response (Fig. 3) after formation of its inducer, ROS (39) (Fig. 2B), and before stringent induction (Fig.