Ying-Tsun Cheng

Aug 11, 2024 | nature.com | Ian R. Monk |Ying-Tsun Cheng |Camilla Predella |Jack Boylan |Ahmed Moustafa |Gaurav Kumar Lohia | +5 more

AbstractStaphylococcus aureus is a pulmonary pathogen associated with substantial human morbidity and mortality. As vaccines targeting virulence determinants have failed to be protective in humans, other factors are likely involved in pathogenesis. Here we analysed transcriptomic responses of human clinical isolates of S. aureus from initial and chronic infections. We observed upregulated collagenase and proline transporter gene expression in chronic infection isolates.