Ying Zhen

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Articles

Structural insights into RNA cleavage by PIWI Argonaute - Nature

Jan 15, 2025 | nature.com | Zhiqing Li |Jing Zhong |Yan Zhang |Jing Huang |Ying Zhen |Zhao Zhang | +1 more

AbstractArgonaute proteins are categorized into AGO and PIWI clades. Across most animal species, AGO-clade proteins are widely expressed in various cell types, and regulate normal gene expression1. By contrast, PIWI-clade proteins predominantly function during gametogenesis to suppress transposons and ensure fertility1,2. Both clades use nucleic acid guides for target recognition by means of base pairing, crucial for initiating target silencing, often through direct cleavage.

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