Zhiqing Li

Jan 15, 2025 | nature.com | Zhiqing Li |Jing Zhong |Yan Zhang |Jing Huang |Ying Zhen |Zhao Zhang | +1 more

AbstractArgonaute proteins are categorized into AGO and PIWI clades. Across most animal species, AGO-clade proteins are widely expressed in various cell types, and regulate normal gene expression1. By contrast, PIWI-clade proteins predominantly function during gametogenesis to suppress transposons and ensure fertility1,2. Both clades use nucleic acid guides for target recognition by means of base pairing, crucial for initiating target silencing, often through direct cleavage.

Apr 24, 2024 | nature.com | Zhiqing Li |Huilin Niu |Miao Gui |Shikui Tu |Zhao Zhang |Chun-Qing Song | +2 more

AbstractThe PIWI-interacting RNA (piRNA) pathway is an adaptive defense system wherein piRNAs guide PIWI family Argonaute proteins to recognize and silence ever-evolving selfish genetic elements and ensure genome integrity. Driven by this intensive host–pathogen arms race, the piRNA pathway and its targeted transposons have coevolved rapidly in a species-specific manner, but how the piRNA pathway adapts specifically to target silencing in mammals remains elusive.

Aug 10, 2023 | dovepress.com | Zhiqing Li

Back to Journals » International Journal of Nanomedicine » Volume 18 Authors Li Z Received 10 August 2023 Accepted for publication 11 August 2023 Published 17 August 2023 Volume 2023:18 Pages 4681—4682 DOI https://doi.org/10.2147/IJN.S434825 Zhiqing Li Department of Burns, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, People’s Republic of China Correspondence: Zhiqing Li, Department of Burns, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, People’s...

Jun 23, 2023 | biorxiv.org | Zhiqing Li |Zhenzhen Li |Lili Li |Lin Zeng

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