Yinming Liang

Sep 25, 2024 | nature.com | Yinming Liang

AbstractThe downregulation of Cadm4 (Cell adhesion molecular 4) is a prominent feature in demyelination diseases, yet, the underlying molecular mechanism remains elusive. Here, we reveal that Cadm4 undergoes specific palmitoylation at cysteine-347 (C347), which is crucial for its stable localization on the plasma membrane (PM). Mutation of C347 to alanine (C347A), blocking palmitoylation, causes Cadm4 internalization from the PM and subsequent degradation.

Sep 13, 2024 | nature.com | Shiqian Qi |Yinming Liang |Tianyu Wang

AbstractRap2b, a proto-oncogene upregulated in colorectal cancer (CRC), undergoes protein S-palmitoylation at specific C-terminus sites (C176/C177). These palmitoylation sites are crucial for Rap2b localization on the plasma membrane (PM), as mutation of C176 or C177 results in cytosolic relocation of Rap2b. Our study demonstrates that Rap2b influences cell migration and invasion in CRC cells, independent of proliferation, and this activity relies on its palmitoylation.

Dec 5, 2023 | science.org | Yi Jiang |Huicong Liu |Leslie K. Ferrarelli |Peipei Yan |Can Wu |Luxian Lv | +7 more

Palmitoylated Sept8-204 modulates learning and anxiety by regulating filopodia arborization and actin dynamics Huicong Liu https://orcid.org/0009-0002-9461-3133, Peipei Yan https://orcid.org/0009-0008-1783-9597, [...] , Can Wu, Muding Rao https://orcid.org/0000-0001-9399-2333, [...] , Jiangli Zhu, Luxian Lv, Wenqiang Li https://orcid.org/0000-0002-0833-246X, Yinming Liang https://orcid.org/0000-0001-9174-4037, Shiqian Qi https://orcid.org/0000-0002-7589-8877, [...] , Kefeng Lu...