Yizhou Yu

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Articles

Mitochondrial One-Carbon Metabolism and Alzheimer’s Disease

Jun 7, 2024 | mdpi.com | Yizhou Yu |L. Martins |L. Miguel

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Genome-wide CRISPR/Cas9 screen shows that loss of GET4 increases mitochondria-endoplasmic reticulum contact sites and is neuroprotective - Cell Death & Disease

Mar 10, 2024 | nature.com | Emma Wilson |Yizhou Yu |Nikolaos Patikas |Julien Prudent |L. Martins |Georgina E. Lindop | +1 more

AbstractOrganelles form membrane contact sites between each other, allowing for the transfer of molecules and signals. Mitochondria-endoplasmic reticulum (ER) contact sites (MERCS) are cellular subdomains characterized by close apposition of mitochondria and ER membranes. They have been implicated in many diseases, including neurodegenerative, metabolic, and cardiac diseases. Although MERCS have been extensively studied, much remains to be explored.
The long-term health outcomes, pathophysiological mechanisms and multidisciplinary management of long COVID - Signal Transduction and Targeted Therapy

Oct 31, 2023 | nature.com | Yizhou Yu |Weimin Li

AbstractThere have been hundreds of millions of cases of coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). With the growing population of recovered patients, it is crucial to understand the long-term consequences of the disease and management strategies.
Links between Sleep Apnoea and Insomnia in a British Cohort

Sep 11, 2023 | mdpi.com | Yizhou Yu

1. IntroductionPoor sleep is a major health, economic, and societal burden [1]. Disturbed sleep can negatively impact mood, cognitive performance, and quality of life [2]. Sleep disturbances are common in neurological diseases [3] and the prevalence of sleep-related problems increases with age [4]. With an ageing population, understanding the causes of poor sleep represents an important public health question. The most prevalent causes of poor sleep are sleep apnoea and insomnia.