Yohan Lee

Nov 8, 2024 | biorxiv.org | Yohan Lee |Feng Yuan |Jeanne C. Stachowiak |Jerry L. Cabriales

AbstractTimely and precise assembly of protein complexes on membrane surfaces is essential to the physiology of living cells. Recently, protein phase separation has been observed at cellular membranes, suggesting it may play a role in the assembly of protein complexes. Inspired by these findings, we observed that protein condensates on one side of a planar suspended membrane spontaneously colocalized with those on the opposite side.

Sep 29, 2024 | biola.edu | Yohan Lee

Dr. Yohan Lee has led advanced technology organizations for over 20 years in commercial industry, education, and government. He has been privileged to serve as a civil scientist (U.S. National Institutes of Health), Principal Investigator (Google AI), Chief Science Officer (Riiid Labs, Inc.), and CEO (Scaled Entelechy, Inc).

Jan 7, 2024 | nature.com | Yohan Lee

Biomolecules, such as proteins and nucleic acids, spontaneously condense into functional clusters in cells in response to external environments through phase separation. Recent studies have suggested that these clusters, called biomolecular condensates, participate in the assembly of pivotal structures at biological membrane surfaces, including immunological synapses, focal adhesions and endocytic vesicles.

Dec 3, 2023 | nature.com | Yohan Lee |Sujin Park |Feng Yuan

AbstractLiquid-liquid phase separation of proteins occurs on both surfaces of cellular membranes during diverse physiological processes. In vitro reconstitution could provide insight into the mechanisms underlying these events. However, most existing reconstitution techniques provide access to only one membrane surface, making it difficult to probe transmembrane phenomena.