Yong-Kyung Kim

Nov 25, 2023 | nature.com | Kristen Wells |Aliya F. Spigelman |Xiong Liu |Yong-Kyung Kim

AbstractInsulin secretion is a tightly regulated process that is vital for maintaining blood glucose homeostasis. Although the molecular components of insulin granule trafficking and secretion are well established, how they are regulated to rapidly fine-tune secretion in response to changing environmental conditions is not well characterized. Recent studies have determined that dysregulation of RNA-binding proteins (RBPs) and aberrant mRNA splicing occurs at the onset of diabetes.