Yonghu Sun

Jul 14, 2024 | nature.com | Zhenzhen Wang |Zhe Wang |Yonghu Sun |Hong liu

AbstractBullous pemphigoid (BP) is a type 2 inflammation- and immunity-driven skin disease, yet a comprehensive understanding of the immune landscape, particularly immune-stromal crosstalk in BP, remains elusive. Herein, using single-cell RNA sequencing (scRNA-seq) and in vitro functional analyzes, we pinpoint Th2 cells, dendritic cells (DCs), and fibroblasts as crucial cell populations.