Yonghui Guan

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Development of Peptide Paratope Mimics Derived from the Anti-ROR1 Antibody and Long-Acting Peptide-Drug Conjugates for Targeted Cancer Therapy

Feb 28, 2024 | pubs.acs.org | Yang Zhang |Shuyu Liu |Yonghui Guan |Yiqing Fan
Development of Peptide Paratope Mimics Derived from the Anti-ROR1 Antibody and Long-Acting Peptide-Drug Conjugates for Targeted Cancer Therapy

Feb 28, 2024 | dx.doi.org | Yang Zhang |Yiqing Fan |Shuyu Liu |Yonghui Guan

Antibody-based targeted therapy in cancer faces a challenge due to uneven antibody distribution in solid tumors, hindering effective drug delivery. We addressed this by developing peptide mimetics with nanomolar-range affinity for Receptor Tyrosine Kinase-Like Orphan Receptor 1 (ROR1) using computational methods. These peptides showed both specific targeting and deep penetration in vitro and in vivo.

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