Yang Zhang

2 months ago | onlinelibrary.wiley.com | Ting Lu |Qin Shen |Ying Liu |Yang Zhang

To the Editor, We would like to present a rare and noteworthy case of a 78-year-old male diagnosed with extensive intestinal metastases originating from a primary scalp angiosarcoma.

Jan 15, 2025 | nature.com | Meijun Zhu |Bo-Ya Du |Yan-Qiu Tan |Yang Yang |Yang Zhang |Yong-Fei Wang

Cyclic nucleotide-gated channel 5 (CNGC5), CNGC6, and CNGC9 (CNGC5/6/9 for simplicity) control Arabidopsis root hair (RH) growth by mediating the influx of external Ca2+ to establish and maintain a sharp cytosolic Ca2+ gradient at RH tips. However, the underlying mechanisms for the regulation of CNGCs remain unknown. We report here that calcium dependent protein kinase 1 (CPK1) directly activates CNGC5/6/9 to promote Arabidopsis RH growth. The loss-of-function mutants cpk1-1, cpk1-2, cngc5-1 cngc6-2 cngc9-1 (shrh1/short root hair 1), and cpk1 shrh1 show similar RH phenotypes, including shorter RHs, more RH branching, and dramatically attenuated cytosolic Ca2+ gradients at RH tips. The main CPK1-target sites are identified as Ser20, Ser27, and Ser26 for CNGC5/6/9, respectively, and the corresponding alanine substitution mutants fail to rescue RH growth in shrh1 and cpk1-1, while phospho-mimic versions restore the cytosolic Ca2+ gradient at RH apex and rescue the RH phenotypes in the same Arabidopsis mutants. Thus we discover the CPK1-CNGC modules essential for the Ca2+ signaling regulation and RH growth in Arabidopsis. Cyclic nucleotide-gated channels (CNGCs) contribute to root hair growth through mediating Ca2+ influx at root hair tips. Here calcium dependent protein kinase 1 is found to directly activate CNGCs via phosphorylation and promote root hair growth in Arabidopsis.

Jan 12, 2025 | onlinelibrary.wiley.com | Weiqiang Xu |Devices Ministry |Yang Zhang |Yu Huang

Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description smll202407063-sup-0001-SuppMat.docx7.7 MB Supporting Information smll202407063-sup-0002-SuppMat.xlsx28.1 KB Supporting Information smll202407063-sup-0003-SuppMat.xlsx13.4 KB Supporting Information References 1, , , , , , , , , , , , , , , , , , , , , , , , , Science 2024, 384, 189. 2a) , , , , , ACS Appl. Mater.

Jan 8, 2025 | mdpi.com | Bo Wang |Yang Zhang |Hong-Jian Wang |Jing-De Huang

Open AccessArticle by Hong-Jian Wang 1,2,*, Jing-De Huang 1, Bo Wang 1, Yang Zhang 1 and Jin Wang 1 1School of Intelligent Manufacturing and Aeronautics, Zhuhai College of Science and Technology, Zhuhai 519040, China 2School of Electronic Engineering and Intelligentization, Dongguan University of Technology, Dongguan 523808, China *Author to whom correspondence should be addressed.

Dec 16, 2024 | mdpi.com | Yang Zhang

1. IntroductionChitin, a nitrogen-containing natural biopolymer that is highly prevalent in nature, is mainly derived from the exoskeletons of crustaceans (such as shrimp and crab) and insects and the cell walls of fungi [1]. Although chitin has an annual output of up to 1011 tons, excessive accumulation in nature is not a problem due to its efficient degradation by microorganisms [2,3,4].