Youjun Zhang

Nov 27, 2024 | nature.com | Alisdair R. Fernie |Youjun Zhang

AbstractPaclitaxel rapidly became one of the most effective anticancer drugs. However, the production of paclitaxel is hindered by substantial challenges, particularly considering the significant quantities of drug required and the inherently low concentration of paclitaxel and its intermediates in plants. Paclitaxel is currently produced in a so-called semi-synthesis in which baccatin III is extracted from Taxus species and chemically converted to paclitaxel.

Apr 4, 2024 | biorxiv.org | Richard Dorrell |Youjun Zhang |Yue Liang |Nolwenn Guéguen

AbstractOrganic carbon fixed in chloroplasts through the Calvin Cycle can be diverted towards different metabolic fates, including cytoplasmic and mitochondrial respiration; gluconeogenesis; and synthesis of diverse plastid metabolites via the pyruvate hub. In plants, pyruvate is principally produced via cytoplasmic glycolysis, although a plastid-targeted lower glycolytic pathway is known in non-photosynthetic tissue.

Feb 6, 2024 | cell.com | Fang Liu |Alisdair R. Fernie |Youjun Zhang

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Jan 11, 2024 | biorxiv.org | Richard Dorrell |Youjun Zhang |Yue Liang |Nolwenn Guéguen

AbstractThe authors have withdrawn this manuscript due to a duplicate posting of manuscript number BIORXIV/2022/507166. Therefore, the authors do not wish this work to be cited as reference for the project. If you have any questions, please contact the corresponding author. The correct preprint can be found at doi: 10.1101/2022.09.08.507166

Jan 11, 2024 | biorxiv.org | Richard Dorrell |Youjun Zhang |Yue Liang |Nolwenn Guéguen

AbstractOrganic carbon fixed in chloroplasts through the Calvin Cycle can be diverted towards different metabolic fates, including cytoplasmic and mitochondrial respiration; gluconeogenesis; and synthesis of diverse plastid metabolites via the pyruvate hub. In plants, pyruvate is principally produced via cytoplasmic glycolysis, although a plastid-targeted lower-half glycolytic pathway is known in non-photosynthetic tissue.