Yu Deng

Oct 16, 2024 | science.org | Jourdan Ewoldt |Olivia Gozel |Sebastian Quaade |Yu Deng

Abstractc-di-GAMP was first identified in bacteria to promote colonization, while mammalian 2′3′-cGAMP is synthesized by cGAS to activate STING for innate immune stimulation. However, 2′3′-cGAMP function beyond innate immunity remains elusive. Here, we report that 2′3′-cGAMP promotes cell migration independent of innate immunity. 2′3′-cGAMP interactome analysis identifies the small GTPase Rab18 as a 2′3′-cGAMP binding partner and effector in cell migration control.

Aug 2, 2024 | digitalcommons.library.tmc.edu | Yu Deng |Lacey P. Gleason |Adam Culbertson |Xiaotian Chen

AbstractVariation in availability, format, and standardization of patient attributes across health care organizations impacts patient-matching performance. We report on the changing nature of patient-matching features available from 2010-2020 across diverse care settings. We asked 38 health care provider organizations about their current patient attribute data-collection practices. All sites collected name, date of birth (DOB), address, and phone number.

Jul 8, 2024 | pubs.rsc.org | Jiahao Pan |Yuchen Zhang |Zhentao Pang |Yu Deng

Revealing the Correlation between Size, Structure, and Fluorescence Enhancement in Ag@Au Nanocube Clusters: A High-Content Platform Approach This work presents a high-content platform for investigating the critical interplay between nanoparticle cluster size, structure, and plasma-enhanced fluorescence at single particle level.

Jun 21, 2024 | nature.com | Yu Deng

AbstractEwing sarcoma is a pediatric bone and soft tissue tumor treated with chemotherapy, radiation, and surgery. Despite intensive multimodality therapy, ~50% patients eventually relapse and die of the disease due to chemoresistance. Here, using phospho-profiling, we find Ewing sarcoma cells treated with chemotherapeutic agents activate TAM (TYRO3, AXL, MERTK) kinases to augment Akt and ERK signaling facilitating chemoresistance.

Jun 8, 2024 | onlinelibrary.wiley.com | Shaokun Gong |Ziyang Xiong |Yu Deng |Yang Xiao

Conflict of Interest The authors declare no conflict of interest.