Yu Hou

3 weeks ago | chemistry-europe.onlinelibrary.wiley.com | Yun Li |Meng Su |Yu Hou |Yajun Zheng

Graphical Abstract The Front Cover showcases a “two-in-one” configuration for electrochemistry–mass spectrometry designed to detect transient intermediates with lifetimes ranging from seconds to milliseconds, microseconds, nanoseconds, and even picoseconds. The integration strategies for combining the electrode and ion source are explored, focusing on leveraging inherent electrochemical properties, incorporating two- or three-electrode systems, and utilizing bipolar electrodes.

2 months ago | chemistry-europe.onlinelibrary.wiley.com | Yun Li |Meng Su |Yu Hou |Yajun Zheng

Identifying short-lived transient intermediates is challenging due to their brief lifetimes (as short as nanoseconds, and even picoseconds) and therefore low concentrations in many chemical processes. Conducting electrochemical reactions within mass spectrometry ion sources (i.e., insource or in situ EC-MS) offers the advantage of minimizing the distance between the electrodes and the mass spectrometer, thereby improving the detection of transient intermediates.

Dec 19, 2024 | mdpi.com | Yu Hou

1. IntroductionThe DEAD-box RNA helicase family, a subset of the helicase superfamily II, is one of the largest helicases families found in eukaryotes, archaea, and bacteria [1]. Characterized by the conserved Asp-Glu-Ala-Asp (DEAD) motif, this family includes 26 members in Saccharomyces cerevisiae and 37 members in Homo sapiens [2,3].

Sep 27, 2024 | nature.com | Yu Hou

AbstractHematopoietic stem cells (HSCs) are vital for the differentiation of all mature blood cells, with their homeostasis being tightly regulated by intrinsic and extrinsic factors. Alternative splicing, mediated by the spliceosome complex, plays a crucial role in regulating HSC homeostasis by increasing protein diversity. This study focuses on the ATP-dependent RNA helicase DHX16, a key spliceosome component, and its role in HSC regulation.

Sep 12, 2024 | pubs.acs.org | Yi Karl Tai |Yu Hou |Shen Cao |Xin Zhe Liu

Bioactive Constituents, Metabolites, and FunctionsSeptember 12, 2024 Xin Zhe Liu Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, Molecular Medicine Research Center, College of Pharmacy, Yanbian University, Yanji, Jilin Province 133002, China Yi Tai Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, Molecular Medicine Research Center, College of Pharmacy, Yanbian University, Yanji, Jilin Province 133002, China Yu Bao Hou...