Meng Su

3 weeks ago | chemistry-europe.onlinelibrary.wiley.com | Yun Li |Meng Su |Yu Hou |Yajun Zheng

Identifying short-lived transient intermediates is challenging due to their brief lifetimes (as short as nanoseconds, and even picoseconds) and therefore low concentrations in many chemical processes. Conducting electrochemical reactions within mass spectrometry ion sources (i.e., insource or in situ EC-MS) offers the advantage of minimizing the distance between the electrodes and the mass spectrometer, thereby improving the detection of transient intermediates.

2 months ago | preprints.org | Ge Qu |Jia Zhou |Yusheng Shi |Meng Su

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Mar 14, 2024 | dx.doi.org | Meng Su |Samuel Roberts |John Sutherland

Download Hi-Res ImageDownload to MS-PowerPointCite This:J. Am. Chem. Soc. 2024, XXXX, XXXRETURN TO ARTICLES ASAPPREVArticleNEXTMeng SuMRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, U.K., Samuel J. RobertsMRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, U.K., and *Cite this: J. Am. Chem. Soc. 2024, XXXX, XXX.

Mar 14, 2024 | pubs.acs.org | Meng Su |Samuel Roberts |John Sutherland

Download Hi-Res ImageDownload to MS-PowerPointCite This:J. Am. Chem. Soc. 2024, XXXX, XXXRETURN TO ARTICLES ASAPPREVArticleNEXTMeng SuMRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, U.K., Samuel J. RobertsMRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, U.K., and *Cite this: J. Am. Chem. Soc. 2024, XXXX, XXX.

Dec 18, 2023 | biorxiv.org | Meng Su |Samuel Roberts |John Sutherland

AbstractThe ribosome is an entropy trap that brings the 3′-aminoacyl- and 3′-peptidyl-termini of two tRNAs together to enable peptidyl transfer. The two tRNAs are bound through their acceptor stems to the peptidyl-transferase centre of the large ribosomal subunit and through their anticodon loops to mRNA at the subunit interface. The latter interaction involving contiguous anticodon:codon pairing is augmented by interactions with the decoding centre of the small ribosomal subunit.