Yuanzhong Pan

2 weeks ago | biorxiv.org | Yuanzhong Pan |Priscilla Chan |Jeremy Rich |Steve Kay

AbstractGlioblastoma (GBM) remains one of the most aggressive adult cancers, with limited treatment options due to an incomplete understanding of its biology. GBM exhibits different transcriptional subtypes, among which the mesenchymal (mGBM) variant is associated with a particularly aggressive nature and poor outcomes. Developing models that capture mGBM phenotypes could offer new insights into its biology and therapeutic vulnerabilities.