Jeremy Rich

2 weeks ago | biorxiv.org | Yuanzhong Pan |Priscilla Chan |Jeremy Rich |Steve Kay

AbstractGlioblastoma (GBM) remains one of the most aggressive adult cancers, with limited treatment options due to an incomplete understanding of its biology. GBM exhibits different transcriptional subtypes, among which the mesenchymal (mGBM) variant is associated with a particularly aggressive nature and poor outcomes. Developing models that capture mGBM phenotypes could offer new insights into its biology and therapeutic vulnerabilities.

Nov 5, 2024 | cell.com | Jeremy Rich

1UPMC Hillman Cancer Center, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA 2Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA 3Brain Tumor Biology and Therapy Lab, Department of Neurosurgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA 4Division of Regenerative Medicine, Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, CA 92037, USA...

Mar 18, 2024 | nature.com | Ya Cui |Wei Li |Jeremy Rich

AbstractGlioblastoma is one of the most lethal malignant cancers, displaying striking intratumor heterogeneity, with glioblastoma stem cells (GSCs) contributing to tumorigenesis and therapeutic resistance. Pharmacologic modulators of ubiquitin ligases and deubiquitinases are under development for cancer and other diseases.