Yuhao Gu

Dec 3, 2024 | nature.com | Yuhao Gu |Anqi Wei |Yong Jiang |Feng Zhu |Jingyu Yao |Xuanang Wu | +1 more

AbstractSchizophrenia is a severe neuropsychiatric disease, but the initiation mechanisms are unclear. Although antipsychotics are effective against positive symptoms, therapeutic interventions for negative symptoms are limited due to the lack of pathophysiological mechanisms. Here we identify synaptotagmin-11 (Syt11) as a potential genetic risk factor and dopamine over-transmission as a mechanism in the development of schizophrenia.