Xuanang Wu

Dec 3, 2024 | nature.com | Yuhao Gu |Anqi Wei |Yong Jiang |Feng Zhu |Jingyu Yao |Xuanang Wu | +1 more

AbstractSchizophrenia is a severe neuropsychiatric disease, but the initiation mechanisms are unclear. Although antipsychotics are effective against positive symptoms, therapeutic interventions for negative symptoms are limited due to the lack of pathophysiological mechanisms. Here we identify synaptotagmin-11 (Syt11) as a potential genetic risk factor and dopamine over-transmission as a mechanism in the development of schizophrenia.

Jan 3, 2024 | nature.com | Yong Jiang |Jingyu Yao |Zhuan Zhou |Zuying Chai |Xinjiang Kang |Feng Wei | +2 more

AbstractThe central mechanisms underlying pain chronicity remain elusive. Here, we identify a reciprocal neuronal circuit in mice between the anterior cingulate cortex (ACC) and the ventral tegmental area (VTA) that mediates mutual exacerbation between hyperalgesia and allodynia and their emotional consequences and, thereby, the chronicity of neuropathic pain.