Yulin Dai

3 weeks ago | digitalcommons.library.tmc.edu | Wendao Liu |Johnathan D Jia |Yulin Dai |Wenhao Chen

AbstractUnderstanding the molecular mechanisms of coronavirus disease 2019 (COVID-19) pathogenesis and immune response is vital for developing therapies. Single-cell RNA sequencing has been applied to delineate the cellular heterogeneity of the host response toward COVID-19 in multiple tissues and organs. Here, we review the applications and findings from over 80 original COVID-19 single-cell RNA sequencing studies as well as many secondary analysis studies.

Mar 17, 2024 | nature.com | Brisa S. Fernandes |Yulin Dai |Ole A. Andreassen |Nitesh Enduru

AbstractThe occurrence of immune disease comorbidities in Alzheimer’s disease (AD) has been observed in both epidemiological and molecular studies, suggesting a neuroinflammatory basis in AD. However, their shared genetic components have not been systematically studied. Here, we composed an atlas of the shared genetic associations between 11 immune-mediated diseases and AD by analyzing genome-wide association studies (GWAS) summary statistics.