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Dec 11, 2024 | 
journals.sagepub.com | Andrew Morris |Pål Møller |Ole A. Andreassen |Bayram C. Akdeniz
Get full access to this articleView all access and purchase options for this article. References1. Sung H, et al. ‘Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin 2021; 71: 209–249. 2. Ligtenberg MJL, et al. Heritable somatic methylation and inactivation of MSH2 in families with Lynch syndrome due to deletion of the 3’ exons of TACSTD1. Nat Genet 2009; 41: 112–117. 3. Dominguez-Valentin M, et al.
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Nov 4, 2024 | 
nature.com | Christoph Abe |Francesco Benedetti |Erlend Bøen |Katharina Brosch |Erick J. Canales-Rodriguez |Torbjørn Elvsåshagen | +34 more
AbstractAlthough specific risk factors for brain alterations in bipolar disorders (BD) are currently unknown, obesity impacts the brain and is highly prevalent in BD. Gray matter correlates of obesity in BD have been well documented, but we know much less about brain white matter abnormalities in people who have both obesity and BD.
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Sep 26, 2024 | 
nature.com | Mary Barker |Kadri Koiv |Ingibjörg Magnúsdóttir |Hannah Milbourn |Bin Wang |Gillian Murphy | +15 more
AbstractIndividuals with mental illness are at higher risk of severe COVID-19 outcomes. However, previous studies on the uptake of COVID-19 vaccination in this population have reported conflicting results.
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Aug 29, 2024 | 
nature.com | Pol Sole-Navais |Xiaoping Wu |Marc Vaudel |Abigail L. LaBella |Øyvind Helgeland |Christopher Flatley | +9 more
AbstractJaundice affects almost all neonates in their first days of life and is caused by the accumulation of bilirubin. Although the core biochemistry of bilirubin metabolism is well understood, it is not clear why some neonates experience more severe jaundice and require treatment with phototherapy. Here, we present the first genome-wide association study of neonatal jaundice to date in nearly 30,000 parent-offspring trios from Norway (cases ≈ 2000).
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Aug 27, 2024 | 
nature.com | Asmundur Oddsson |Valgerdur Steinthorsdottir |Gudjon R. Oskarsson |Unnur Styrkarsdottir |Gísli H. Halldórsson |Gardar Sveinbjornsson | +22 more
AbstractAge at menopause (AOM) has a substantial impact on fertility and disease risk. While many loci with variants that associate with AOM have been identified through genome-wide association studies (GWAS) under an additive model, other genetic models are rarely considered1. Here through GWAS meta-analysis under the recessive model of 174,329 postmenopausal women from Iceland, Denmark, the United Kingdom (UK; UK Biobank) and Norway, we study low-frequency variants with a large effect on AOM.
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Aug 21, 2024 | 
nature.com | Milin Kim |Esten Leonardsen |Geir Selbæk |Nils Eiel Steen |Olav B. Smeland |Geneviève Richard | +4 more
AbstractThe cerebellum is linked to motor coordination, cognitive and affective processing, in addition to a wide range of clinical illnesses. To enable robust quantification of individual cerebellar anatomy relative to population norms, we mapped the normative development and aging of the cerebellum across the lifespan using brain scans of >54,000 participants. We estimated normative models at voxel-wise spatial precision, enabling integration with cerebellar atlases.
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Jul 29, 2024 | 
medrxiv.org | Eric T. Monson |Ole A. Andreassen |Olatunde O. Ayinde |Cosmin Bejan
Ole Andreassen: Consultant to Cortechs.ai and Precision-Health.ai, and received speaker's honorarium from Lundbeck, Sunovion, Janssen and Otsuka.
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Jul 22, 2024 | 
nature.com | David Westergaard |Valgerdur Steinthorsdottir |Palle Duun Rohde |Xiaoping Wu |Frank Geller |Pol Sole-Navais | +22 more
AbstractBleeding in early pregnancy and postpartum hemorrhage (PPH) bear substantial risks, with the former closely associated with pregnancy loss and the latter being the foremost cause of maternal death, underscoring the severe impact on maternal–fetal health. We identified five genetic loci linked to PPH in a meta-analysis.
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Jul 17, 2024 | 
nature.com | Amanda Hughes |Fartein Ask Torvik |Elsje van Bergen |Elizabeth C Corfield |Ole A. Andreassen |Eivind Ystrom | +3 more
AbstractChildren born to parents with fewer years of education are more likely to have depression, anxiety, and attention-deficit hyperactivity disorder (ADHD), but it is unclear to what extent these associations are causal. We estimated the effect of parents’ educational attainment on children’s depressive, anxiety, and ADHD traits at age 8 years, in a sample of 40,879 Norwegian children born in 1998–2009 and their parents.
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Jun 16, 2024 | 
nature.com | Jacob Bergstedt |Ziyan Ma |Shuyang Yao |Nadine Staples Parker |Oleksandr Frei |Joeri J. Meijsen | +12 more
AbstractMajor depressive disorder (MDD) and cardiovascular disease (CVD) are often comorbid, resulting in excess morbidity and mortality. Here we show that CVDs share most of their genetic risk factors with MDD. Multivariate genome-wide association analysis of shared genetic liability between MDD and atherosclerotic CVD revealed seven loci and distinct patterns of tissue and brain cell-type enrichments, suggesting the involvement of the thalamus.
