Yunpeng Gu

Mar 14, 2024 | elifesciences.org | Guangqin Wang |Yunpeng Gu |zhiyong Liu |houyu Zhang

eLife assessment In this valuable study, the authors explore regulatory cascades governing mammalian cochlear hair cell development and survival. They confirm previous studies that the transcription factors Pou4f3 and Gfi1 are necessary for hair cell survival and use compelling evidence to demonstrate that the RNA-binding protein gene RBM24 is regulated by Pou4f3, but not Gfi1.

Jan 8, 2024 | biorxiv.org | Guangqin Wang |Yunpeng Gu |zhiyong Liu

AbstractMammals harbor a limited number of sound-receptor hair cells (HCs) that cannot be regenerated after damage. Thus, investigating the underlying molecular mechanisms that maintain HC survival is crucial for preventing hearing impairment. Intriguingly, Pou4f3-/- or Gfi1-/- HCs form initially but then rapidly degenerate, whereas Rbm24-/- HCs degenerate considerably later. However, the transcriptional cascades involving Pou4f3, Gfi1, and Rbm24 remains undescribed.

Jun 22, 2023 | biorxiv.org | Guangqin Wang |Yunpeng Gu |zhiyong Liu

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